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TME-responsive multifunctional nanoparticles
Conventional nano-drug delivery systems based on a single therapeutic mechanism face inherent limitations in tumor accumulation and variable treatment responses. Our research introduces a multifunctional nanoplatform that integrates ROS-mediated chemodynamic therapy (CDT) with heat-induced photothermal therapy (PTT), aiming to overcome these challenges. This approach combines multi-reactive therapeutic mechanisms with precise targeting, highlighting its potential as a next-generation cancer treatment strategy. Furthermore, this platform can be expanded into a precision-tailored nanotherapeutic system applicable to various solid tumor models.
Development of lyophilized Cell Vaccine
We developed a cancer cell vaccine by loading damage-associated molecular patterns (DAMPs) and pathogen-associated molecular patterns (PAMPs) onto cancer cells through the treatment of chemotherapy and E. coli, followed by lyophilization with Cryoprotectant.
The incorporation of DAMPs was verified by assessing changes in DAMP levels after chemotherapy treatment, while the optimal conditions for PAMP loading were established by evaluating the encapsulation efficiency and cell damage of cancer cell after treatment with E. coli at various MOI values.
Curcumin-metal nanomedicine for cancer therapy
We are developing an anticancer therapy based on the natural compound curcumin. Although curcumin has been reported to exhibit a wide range of anticancer effects, its poor stability and low bioavailability have limited its clinical application. To overcome these challenges, we conjugate curcumin with metal ions to enhance its chemical stability and biological activity, and further encapsulate it into nanoparticles for targeted delivery to tumor tissues. This nanoplatform not only strengthens the induction of cancer cell death but also ensures sustained drug retention in the body and effective tumor suppression, thereby addressing the limitations of conventional therapies.
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+82-02-961-0693
Location
Room B123, Department of Regulatory Sciences, College of Pharmacy, 26 Kyunghee-daero, Dongdaemun-gu, Seoul, 02447, Republic of Korea